2k1j: Difference between revisions

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{{STRUCTURE_2k1j|  PDB=2k1j  |  SCENE=  }}  
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'''Plan homeodomain finger of tumour supressor ING4'''
===Plan homeodomain finger of tumour supressor ING4===




==Overview==
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Plant homeodomain (PHD) fingers are frequently present in proteins involved in chromatin remodelling, and some of them bind to histones. The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors. We have determined the structure of ING4 PHD, and characterised its binding to phosphoinositides and histone methylated tails. In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4.
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{{ABSTRACT_PUBMED_17157298}}


==About this Structure==
==About this Structure==
2K1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jmq 2jmq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1J OCA].  
2K1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jmq 2jmq]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1J OCA].  


==Reference==
==Reference==
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[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
[[Category: Zn]]
[[Category: Zn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:57:35 2008''

Revision as of 04:57, 28 July 2008

File:2k1j.png

Template:STRUCTURE 2k1j

Plan homeodomain finger of tumour supressor ING4Plan homeodomain finger of tumour supressor ING4

Template:ABSTRACT PUBMED 17157298

About this StructureAbout this Structure

2K1J is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2jmq. Full experimental information is available from OCA.

ReferenceReference

Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4., Palacios A, Garcia P, Padro D, Lopez-Hernandez E, Martin I, Blanco FJ, FEBS Lett. 2006 Dec 22;580(30):6903-8. Epub 2006 Nov 30. PMID:17157298

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