4r4t: Difference between revisions

<table><tr><td colspan='2'>[[4r4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R4T FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3J0:5-{4-[({[4-(5-CARBOXYFURAN-2-YL)PHENYL]CARBONOTHIOYL}AMINO)METHYL]PHENYL}-1-(3,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC+ACID'>3J0</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r4t OCA], [https://pdbe.org/4r4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r4t RCSB], [https://www.ebi.ac.uk/pdbsum/4r4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r4t ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>  Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>  

*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]

[[Category: Homo sapiens]]

[[Category: Chazin WJ]]

[[Category: Feldkamp MD]]

[[Category: Fesik SW]]

[[Category: Frank AO]]

[[Category: Kennedy JP]]

[[Category: Patrone JD]]

[[Category: Pelz NF]]

[[Category: Rossanese OW]]

[[Category: Sousa-Fagundes EM]]

[[Category: Vangamudi B]]

[[Category: Waterson AG]]