6odb: Difference between revisions

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-'''Unreleased structure'''
-The entry 6odb is ON HOLD  until Paper Publication
+==Crystal structure of HDAC8 in complex with compound 3==
+<StructureSection load='6odb' size='340' side='right'caption='[[6odb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Zheng, X., Conti, C., Caravella, J., Zablocki, M.-M., Bair, K., Barczak, N., Han, B., Lancia Jr., D., Liu, C., Martin, M., Ng, P.Y., Rudnitskaya, A., Thomason, J.J., Garcia-Dancey, R., Hardy, C., Lahdenranta, J., Leng, C., Li, P., Pardo, E., Saldahna, A., Tan, T., Toms, A.V., Yao, L., Zhang, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6odb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ODB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ODB FirstGlance]. <br>
-Description: Crystal structure of HDAC8 in complex with compound 3
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=M8G:N-{2-[(1E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl]phenyl}-2-phenoxybenzamide'>M8G</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_deacetylase Histone deacetylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.98 3.5.1.98] </span></td></tr>
-[[Category: Tan, T]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6odb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6odb OCA], [http://pdbe.org/6odb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6odb RCSB], [http://www.ebi.ac.uk/pdbsum/6odb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6odb ProSAT]</span></td></tr>
-[[Category: Rudnitskaya, A]]
+</table>
-[[Category: Leng, C]]
+== Function ==
+[[http://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN]] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Histone deacetylase]]
+[[Category: Large Structures]]
+[[Category: Bair, K]]
 [[Category: Barczak, N]]
-[[Category: Lancia Jr]]
+[[Category: Caravella, J]]
+[[Category: Conti, C]]
+[[Category: Garcia-Dancey, R]]
 [[Category: Han, B]]
-[[Category: Zablocki, M.-M]]
+[[Category: Hardy, C]]
-[[Category: Yao, L]]
+[[Category: Lahdenranta, J]]
+[[Category: Lancia, D]]
+[[Category: Leng, C]]
+[[Category: Li, P]]
+[[Category: Liu, C]]
 [[Category: Martin, M]]
-[[Category: Bair, K]]
+[[Category: Ng, P Y]]
-[[Category: Toms, A.V]]
 [[Category: Pardo, E]]
-[[Category: Zheng, X]]
+[[Category: Rudnitskaya, A]]
-[[Category: Liu, C]]
-[[Category: Conti, C]]
-[[Category: Hardy, C]]
-[[Category: Lahdenranta, J]]
-[[Category: Caravella, J]]
 [[Category: Saldahna, A]]
-[[Category: Garcia-Dancey, R]]
+[[Category: Tan, T]]
+[[Category: Thomason, J J]]
+[[Category: Toms, A V]]
+[[Category: Yao, L]]
+[[Category: Zablocki, M M]]
 [[Category: Zhang, C]]
-[[Category: D]]
+[[Category: Zheng, X]]
-[[Category: Li, P]]
+[[Category: Hdac8]]
-[[Category: Ng, P.Y]]
+[[Category: Hydrolase]]
-[[Category: Thomason, J.J]]
+[[Category: Hydroxamic acid]]