4qvb: Difference between revisions

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 <StructureSection load='4qvb' size='340' side='right'caption='[[4qvb]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4qvb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_7199-99 Mycobacterium tuberculosis 7199-99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QVB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4qvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_7199-99 Mycobacterium tuberculosis 7199-99]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QVB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F42:COENZYME+F420'>F42</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=F42:COENZYME+F420'>F42</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT7199_1184 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1138877 Mycobacterium tuberculosis 7199-99])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qvb OCA], [https://pdbe.org/4qvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qvb RCSB], [https://www.ebi.ac.uk/pdbsum/4qvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qvb ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qvb OCA], [http://pdbe.org/4qvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qvb RCSB], [http://www.ebi.ac.uk/pdbsum/4qvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qvb ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/F420R_MYCTU F420R_MYCTU] F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo (PubMed:27364382). Binds coenzyme F420, but does not bind FMN or other flavins (PubMed:25644473). Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates (PubMed:25644473).<ref>PMID:25644473</ref> <ref>PMID:27364382</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 [[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis 7199-99]]
-[[Category: Abell, C]]
+[[Category: Abell C]]
-[[Category: Garboczi, D N]]
+[[Category: Barry III CE]]
-[[Category: Gittis, A G]]
+[[Category: Garboczi DN]]
-[[Category: III, C E.Barry]]
+[[Category: Gittis AG]]
-[[Category: Mashalidis, E H]]
+[[Category: Mashalidis EH]]
-[[Category: Tomczak, A]]
+[[Category: Tomczak A]]
-[[Category: Oxidoreductase]]