4p7f: Difference between revisions

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<StructureSection load='4p7f' size='340' side='right'caption='[[4p7f]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
<StructureSection load='4p7f' size='340' side='right'caption='[[4p7f]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4p7f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7F FirstGlance]. <br>
<table><tr><td colspan='2'>[[4p7f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P7F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PI:HYDROGENPHOSPHATE+ION'>PI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PI:HYDROGENPHOSPHATE+ION'>PI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p7k|4p7k]], [[4p7g|4p7g]], [[4p7j|4p7j]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7f OCA], [https://pdbe.org/4p7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p7f RCSB], [https://www.ebi.ac.uk/pdbsum/4p7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7f ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Comt, Comt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7f OCA], [http://pdbe.org/4p7f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7f RCSB], [http://www.ebi.ac.uk/pdbsum/4p7f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/COMT_MOUSE COMT_MOUSE]] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.  
[https://www.uniprot.org/uniprot/COMT_MOUSE COMT_MOUSE] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Catechol O-methyltransferase|Catechol O-methyltransferase]]
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Catechol O-methyltransferase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Benz, J]]
[[Category: Benz J]]
[[Category: Ehler, A]]
[[Category: Ehler A]]
[[Category: Rudolph, M G]]
[[Category: Rudolph MG]]
[[Category: Schlatter, D]]
[[Category: Schlatter D]]
[[Category: Alternative initiation]]
[[Category: Catecholamine metabolism]]
[[Category: Cell membrane]]
[[Category: Conformational change]]
[[Category: Enzyme mechanism]]
[[Category: Metal-binding]]
[[Category: Methyltransferase]]
[[Category: Neurotransmitter degradation]]
[[Category: Phosphoprotein]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane anchor]]

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