6j4t: Difference between revisions

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-'''Unreleased structure'''
-The entry 6j4t is ON HOLD  until Paper Publication
+==Crystal structure of arabidopsis ADAL complexed with IMP==
+<StructureSection load='6j4t' size='340' side='right'caption='[[6j4t]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6j4t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J4T FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j4t OCA], [http://pdbe.org/6j4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j4t RCSB], [http://www.ebi.ac.uk/pdbsum/6j4t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j4t ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Arabidopsis thaliana aminohydrolase (AtADAL) has been shown to be involved in the metabolism of N(6)-methyl-AMP, a proposed intermediate during m(6)A-modified RNA metabolism, which can be subsequently incorporated into newly synthesized RNA by Pol II. It has been proposed that AtADAL will prevent N(6)-methyl-AMP reuse and catabolize it to inosine monophosphate (IMP). Here, we have solved the crystal structures of AtADAL in the apo form and in complex with GMP and IMP in the presence of Zn(2+). We have identified the substrate-binding pocket of AtADAL and compared it with that for adenosine deaminase (ADA), adenine deaminase (ADE) and AMP deaminase (AMPD) from multiple species. The comparisons reveal that plant ADAL1 may have the potential ability to catalyze different alkyl-group substituted substrates.
-Authors: Wu, B.X., Zhang, D., Nie, H.B., Shen, S.L., Li, S.S., Patel, D.J.
+Structure of Arabidopsis thaliana N(6)-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N(6)-methyl-AMP recognition and processing.,Wu B, Zhang D, Nie H, Shen S, Li Y, Li S RNA Biol. 2019 Jul 18:1-9. doi: 10.1080/15476286.2019.1642712. PMID:31318636<ref>PMID:31318636</ref>
-Description: Crystal structure of arabidopsis ADAL complexed with IMP
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Shen, S.L]]
+<div class="pdbe-citations 6j4t" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Li, S S]]
+[[Category: Nie, H B]]
+[[Category: Patel, D J]]
+[[Category: Shen, S L]]
+[[Category: Wu, B X]]
 [[Category: Zhang, D]]
-[[Category: Patel, D.J]]
+[[Category: Arabidopsis]]
-[[Category: Nie, H.B]]
+[[Category: Complex]]
-[[Category: Li, S.S]]
+[[Category: Deaminase]]
-[[Category: Wu, B.X]]
+[[Category: Gmp]]
+[[Category: Hydrolase]]
+[[Category: M6a]]
+[[Category: N6-mamp]]
+[[Category: Zn]]