6ecn: Difference between revisions

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'''Unreleased structure'''


The entry 6ecn is ON HOLD  until Paper Publication
==HIV-1 CA 1/2-hexamer-EE==
 
<StructureSection load='6ecn' size='340' side='right'caption='[[6ecn]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors: Summers, B.J., Xiong, Y.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ecn]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ECN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ECN FirstGlance]. <br>
Description: HIV-1 CA 1/2-hexamer-EE
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6eco|6eco]], [[6ec2|6ec2]]</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ecn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ecn OCA], [http://pdbe.org/6ecn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ecn RCSB], [http://www.ebi.ac.uk/pdbsum/6ecn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ecn ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GAG_HV1H2 GAG_HV1H2]] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu.  Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.  p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Summers, B J]]
[[Category: Xiong, Y]]
[[Category: Xiong, Y]]
[[Category: Summers, B.J]]
[[Category: Capsid]]
[[Category: Disulfide crosslink]]
[[Category: Viral protein]]

Revision as of 08:50, 21 August 2019

HIV-1 CA 1/2-hexamer-EEHIV-1 CA 1/2-hexamer-EE

Structural highlights

6ecn is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[GAG_HV1H2] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).

6ecn, resolution 3.40Å

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