4c6r: Difference between revisions

<table><tr><td colspan='2'>[[4c6r]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C6R FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c6r OCA], [https://pdbe.org/4c6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c6r RCSB], [https://www.ebi.ac.uk/pdbsum/4c6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c6r ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/RPS4_ARATH RPS4_ARATH]] Disease resistance (R) protein that specifically recognizes the AvrRps4 type III effector avirulence protein from P.syringae (PubMed:10571887, PubMed:15469494, PubMed:19519800). Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein (PubMed:10571887, PubMed:15469494, PubMed:19519800). That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (PubMed:10571887, PubMed:15469494, PubMed:19519800). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792, PubMed:31439793). The combined presence of both regular and alternative RPS4 transcripts with truncated open reading frames (ORFs) is necessary for function (PubMed:17951452). RPS4 function is regulated at multiple levels, including gene expression, alternative splicing, and protein stability (PubMed:17951452). When over-expressed, confers temperature-conditioned EDS1-dependent auto-immunity (PubMed:24146667). Heterodimerization with RRS1 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Abscisic acid deficiency enhances nuclear accumulation of RPS4 and its cell death-inducing activity (PubMed:22454454).<ref>PMID:10571887</ref> <ref>PMID:15469494</ref> <ref>PMID:17951452</ref> <ref>PMID:19519800</ref> <ref>PMID:22454454</ref> <ref>PMID:24146667</ref> <ref>PMID:24744375</ref> <ref>PMID:31439792</ref> <ref>PMID:31439793</ref> <ref>PMID:17951452</ref> <ref>PMID:19519800</ref>  

[[Category: Arabidopsis thaliana]]

[[Category: Bernoux M]]

[[Category: Dodds PN]]

[[Category: Ericsson DJ]]

[[Category: Jones JDG]]

[[Category: Kobe B]]

[[Category: Ma Y]]

[[Category: Parker J]]

[[Category: Sarris P]]

[[Category: Saucet SB]]

[[Category: Segonzac C]]

[[Category: Sohn KH]]

[[Category: Ve T]]

[[Category: Wan L]]

[[Category: Williams SJ]]

[[Category: Zhang X]]