4b93: Difference between revisions

<table><tr><td colspan='2'>[[4b93]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B93 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B93 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vx8|2vx8]], [[4afi|4afi]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b93 OCA], [http://pdbe.org/4b93 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b93 RCSB], [http://www.ebi.ac.uk/pdbsum/4b93 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b93 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/VAMP7_MOUSE VAMP7_MOUSE]] Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.<ref>PMID:15470500</ref>  [[http://www.uniprot.org/uniprot/ANR27_HUMAN ANR27_HUMAN]] May be a Rab21 guanine exchange factor and regulate endosome dynamics (By similarity).