1ft9: Difference between revisions

Revision as of 16:44, 2 May 2008

STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM

OverviewOverview

CooA is a homodimeric transcription factor that belongs to the catabolite activator protein (CAP) family. Binding of CO to the heme groups of CooA leads to the transcription of genes involved in CO oxidation in Rhodospirillum rubrum. The 2.6 A structure of reduced (Fe2+) CooA reveals that His 77 in both subunits provides one heme ligand while the N-terminal nitrogen of Pro 2 from the opposite subunit provides the other ligand. A structural comparison of CooA in the absence of effector and DNA (off state) with that of CAP in the effector and DNA bound state (on state) leads to a plausible model for the mechanism of allosteric control in this class of proteins as well as the CO dependent activation of CooA.

About this StructureAbout this Structure

1FT9 is a Single protein structure of sequence from Rhodospirillum rubrum. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the CO sensing transcription activator CooA., Lanzilotta WN, Schuller DJ, Thorsteinsson MV, Kerby RL, Roberts GP, Poulos TL, Nat Struct Biol. 2000 Oct;7(10):876-80. PMID:11017196 Page seeded by OCA on Fri May 2 16:44:28 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1ft9.jpg|left|200px]]
-<!--The below Structure Template creates the "Structure Box" on the page. It is automatically created and periodically refreshed.  All changes to the Structure Template will be lost EXCEPT for changes in the PDB parameter (setting the PDB file loaded) or the SCENE parameter (setting the initial scene to display when the page is loaded). -->
+<!--
-<!-- STRUCTURE TEMPLATE BEGIN -->
+The line below this paragraph, containing "STRUCTURE_1ft9", creates the "Structure Box" on the page.
-{{Structure
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|PDB= 1ft9 |SIZE=350|CAPTION= <scene name='initialview01'>1ft9</scene>, resolution 2.6&Aring;
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|SITE=
+or leave the SCENE parameter empty for the default display.
-|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
+-->
-|ACTIVITY=
+{{STRUCTURE_1ft9|  PDB=1ft9  |  SCENE=  }}
-|GENE=
-|DOMAIN=
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ft9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ft9 OCA], [http://www.ebi.ac.uk/pdbsum/1ft9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ft9 RCSB]</span>
-}}
-<!-- STRUCTURE TEMPLATE END -->
 '''STRUCTURE OF THE REDUCED (FEII) CO-SENSING PROTEIN FROM R. RUBRUM'''
@@ Line 37: / Line 31: @@
 [[Category: Catabolite gene activator protein]]
 [[Category: Heme sensor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:44:28 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Apr  7 20:46:09 2008''