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==Thaumatin from Thaumatococcus daniellii structure in complex with the europium tris-hydroxymethyltriazoledipicolinate complex at 1.30 A resolution.== | ==Thaumatin from Thaumatococcus daniellii structure in complex with the europium tris-hydroxymethyltriazoledipicolinate complex at 1.30 A resolution.== | ||
<StructureSection load='4bal' size='340' side='right' | <StructureSection load='4bal' size='340' side='right'caption='[[4bal]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bal]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bal]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thaumatococcus_daniellii Thaumatococcus daniellii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BAL FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EU3:EUROPIUM+(III)+ION'>EU3</scene>, <scene name='pdbligand=HM6:4-(4-(HYDROXYMETHYL)-1H-1,2,3-TRIAZOL-1-YL)PYRIDINE-2,6-DICARBOXYLIC+ACID'>HM6</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EU3:EUROPIUM+(III)+ION'>EU3</scene>, <scene name='pdbligand=HM6:4-(4-(HYDROXYMETHYL)-1H-1,2,3-TRIAZOL-1-YL)PYRIDINE-2,6-DICARBOXYLIC+ACID'>HM6</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kwn|1kwn]], [[1lr2|1lr2]], [[1lr3|1lr3]], [[1lxz|1lxz]], [[1ly0|1ly0]], [[1pp3|1pp3]], [[1rqw|1rqw]], [[1thi|1thi]], [[1thu|1thu]], [[1thv|1thv]], [[1thw|1thw]], [[2a7i|2a7i]], [[2blr|2blr]], [[2blu|2blu]], [[2d8o|2d8o]], [[2d8p|2d8p]], [[2vhk|2vhk]], [[2vhr|2vhr]], [[2vi1|2vi1]], [[2vi2|2vi2]], [[2vi3|2vi3]], [[2vi4|2vi4]], [[2vu6|2vu6]], [[2vu7|2vu7]], [[2wbz|2wbz]], [[4axr|4axr]], [[4axu|4axu]], [[4bar|4bar]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1kwn|1kwn]], [[1lr2|1lr2]], [[1lr3|1lr3]], [[1lxz|1lxz]], [[1ly0|1ly0]], [[1pp3|1pp3]], [[1rqw|1rqw]], [[1thi|1thi]], [[1thu|1thu]], [[1thv|1thv]], [[1thw|1thw]], [[2a7i|2a7i]], [[2blr|2blr]], [[2blu|2blu]], [[2d8o|2d8o]], [[2d8p|2d8p]], [[2vhk|2vhk]], [[2vhr|2vhr]], [[2vi1|2vi1]], [[2vi2|2vi2]], [[2vi3|2vi3]], [[2vi4|2vi4]], [[2vu6|2vu6]], [[2vu7|2vu7]], [[2wbz|2wbz]], [[4axr|4axr]], [[4axu|4axu]], [[4bar|4bar]]</div></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bal OCA], [https://pdbe.org/4bal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bal RCSB], [https://www.ebi.ac.uk/pdbsum/4bal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bal ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/THM1_THADA THM1_THADA]] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Thaumatococcus daniellii]] | [[Category: Thaumatococcus daniellii]] | ||
[[Category: Gautier, A]] | [[Category: Gautier, A]] | ||
Revision as of 10:05, 31 August 2022
Thaumatin from Thaumatococcus daniellii structure in complex with the europium tris-hydroxymethyltriazoledipicolinate complex at 1.30 A resolution.Thaumatin from Thaumatococcus daniellii structure in complex with the europium tris-hydroxymethyltriazoledipicolinate complex at 1.30 A resolution.
Structural highlights
Function[THM1_THADA] Taste-modifying protein; intensely sweet-tasting. It is 100000 times sweeter than sucrose on a molar basis. Publication Abstract from PubMedNew trisdipicolinic acid-lanthanide complexes are reported as phasing agents for X-ray crystallography of proteins. It is demonstrated that CuAAC modifications allow protein co-crystallization with low concentration of lanthanide complexes leading to an accurate structure determination. Clicked europium dipicolinate complexes for protein X-ray structure determination.,Talon R, Nauton L, Canet JL, Kahn R, Girard E, Gautier A Chem Commun (Camb). 2012 Nov 12;48(97):11886-8. doi: 10.1039/c2cc36982f. PMID:23123834[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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