5zf2: Difference between revisions

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 ==Crystal structure of Trxlp from Edwardsiella tarda EIB202==
-<StructureSection load='5zf2' size='340' side='right'  caption='[[5zf2]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
+<StructureSection load='5zf2' size='340' side='right'caption='[[5zf2]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5zf2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZF2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5zf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Edwardsiella_tarda_EIB202 Edwardsiella tarda EIB202]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZF2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zf2 OCA], [http://pdbe.org/5zf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zf2 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zf2 OCA], [https://pdbe.org/5zf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zf2 RCSB], [https://www.ebi.ac.uk/pdbsum/5zf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zf2 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/D0Z9P5_EDWTE D0Z9P5_EDWTE]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+It is important that bacterium can coordinately deliver several effectors into host cells to disturb the cellular progress during infection, however, the precise role of effectors in host cell cytosol remains to be resolved. In this study, we identified a new bacterial virulence effector from pathogenic Edwardsiella piscicida, which presents conserved crystal structure to thioredoxin family members and is defined as a thioredoxin-like protein (Trxlp). Unlike the classical bacterial thioredoxins, Trxlp can be translocated into host cells, mimicking endogenous thioredoxin to abrogate ASK1 homophilic interaction and phosphorylation, then suppressing the phosphorylation of downstream Erk1/2- and p38-MAPK signaling cascades. Moreover, Trxlp-mediated inhibition of ASK1-Erk/p38-MAPK axis promotes the pathogenesis of E. piscicida in zebrafish larvae infection model. Taken together, these data provide insights into the mechanism underlying the bacterial thioredoxin as a virulence effector in downmodulating the innate immune responses during E. piscicida infection.
+The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection.,Yang D, Liu X, Xu W, Gu Z, Yang C, Zhang L, Tan J, Zheng X, Wang Z, Quan S, Zhang Y, Liu Q PLoS Pathog. 2019 Jul 17;15(7):e1007917. doi: 10.1371/journal.ppat.1007917. , eCollection 2019 Jul. PMID:31314784<ref>PMID:31314784</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 5zf2" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Quan, S]]
+[[Category: Edwardsiella tarda EIB202]]
-[[Category: Yang, C]]
+[[Category: Large Structures]]
-[[Category: Ask1-mapk signaling cascades]]
+[[Category: Quan S]]
-[[Category: Oxidoreductase]]
+[[Category: Yang C]]
-[[Category: T4ss effector]]
-[[Category: Thioredoxin-like protein]]