6qfb: Difference between revisions

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-'''Unreleased structure'''
-The entry 6qfb is ON HOLD  until Paper Publication
+==Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP==
+<StructureSection load='6qfb' size='340' side='right'caption='[[6qfb]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qfb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QFB FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hxh|6hxh]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ATP_citrate_synthase ATP citrate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.3.8 2.3.3.8] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qfb OCA], [http://pdbe.org/6qfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qfb RCSB], [http://www.ebi.ac.uk/pdbsum/6qfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qfb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: ATP citrate synthase]]
+[[Category: Large Structures]]
+[[Category: Verschueren, K]]
+[[Category: Verstraete, K]]
+[[Category: Acetyl-coa]]
+[[Category: Atp citrate lyase]]
+[[Category: Central metabolism]]
+[[Category: Citrate shuttle]]
+[[Category: Citryl-coa]]
+[[Category: Lipogenesis]]
+[[Category: Lyase]]
+[[Category: Rtca cycle]]