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==Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana.==
==Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana.==
<StructureSection load='5a2n' size='340' side='right' caption='[[5a2n]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='5a2n' size='340' side='right'caption='[[5a2n]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a2n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4cl4 4cl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A2N FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4cl4 4cl4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a2o|5a2o]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2n OCA], [https://pdbe.org/5a2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2n RCSB], [https://www.ebi.ac.uk/pdbsum/5a2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2n OCA], [http://pdbe.org/5a2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a2n RCSB], [http://www.ebi.ac.uk/pdbsum/5a2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTR7_ARATH PTR7_ARATH]] Dual affinity nitrate transporter. Involved in proton-dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be involved in the basipetal transport of auxin out of the lateral root tips. Acts as a bidirectional transporter involved in root-to-shoot nitrate translocation.<ref>PMID:8453665</ref> <ref>PMID:9844028</ref> <ref>PMID:12606566</ref> <ref>PMID:12509525</ref> <ref>PMID:15319483</ref> <ref>PMID:17148611</ref> <ref>PMID:19766570</ref> <ref>PMID:19633234</ref> <ref>PMID:20627075</ref>
[https://www.uniprot.org/uniprot/PTR7_ARATH PTR7_ARATH] Dual affinity nitrate transporter. Involved in proton-dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be involved in the basipetal transport of auxin out of the lateral root tips. Acts as a bidirectional transporter involved in root-to-shoot nitrate translocation.<ref>PMID:8453665</ref> <ref>PMID:9844028</ref> <ref>PMID:12606566</ref> <ref>PMID:12509525</ref> <ref>PMID:15319483</ref> <ref>PMID:17148611</ref> <ref>PMID:19766570</ref> <ref>PMID:19633234</ref> <ref>PMID:20627075</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Newstead, S]]
[[Category: Large Structures]]
[[Category: Parker, J L]]
[[Category: Newstead S]]
[[Category: Major facilitator superfamily]]
[[Category: Parker JL]]
[[Category: Nitrate]]
[[Category: Npf family]]
[[Category: Nrt1/ptr family]]
[[Category: Pot family]]
[[Category: Transport protein]]
[[Category: Transporter]]

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