6j4q: Difference between revisions

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-'''Unreleased structure'''
-The entry 6j4q is ON HOLD  until Paper Publication
+==Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and functional implications==
+<StructureSection load='6j4q' size='340' side='right'caption='[[6j4q]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6j4q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J4Q FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TQ8:N-[(2S)-4-CHLORO-3-OXO-1-PHENYL-BUTAN-2-YL]-4-METHYL-BENZENESULFONAMIDE'>TQ8</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tubulinyl-Tyr_carboxypeptidase Tubulinyl-Tyr carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.17 3.4.17.17] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j4q OCA], [http://pdbe.org/6j4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j4q RCSB], [http://www.ebi.ac.uk/pdbsum/6j4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j4q ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SVBP_HUMAN SVBP_HUMAN]] Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017).<ref>PMID:20736312</ref> <ref>PMID:27879017</ref> <ref>PMID:29146869</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Tubulinyl-Tyr carboxypeptidase]]
+[[Category: Bao, H]]
+[[Category: Huang, H]]
+[[Category: Wang, N]]
+[[Category: Carboxypeptidase]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor]]
+[[Category: Microtubule]]
+[[Category: Tpck]]
+[[Category: Tubulin]]