Collagenase (non-MMP): Difference between revisions
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== 3D Structures of collagenase == | |||
[[Collagenase 3D structures]] | |||
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== 3D Structures of collagenase == | == 3D Structures of collagenase == | ||
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**[[4ar1]] – ChColH peptidase domain <br /> | **[[4ar1]] – ChColH peptidase domain <br /> | ||
**[[4arf]] – CtColH peptidase domain + peptide inhibitor <br /> | **[[4arf]] – CtColH peptidase domain + peptide inhibitor <br /> | ||
**[[5o7e]] – ColH peptidase domain + inhibitor – ''Hathewaya histolytica''<br /> | |||
*Collagenase T | *Collagenase T | ||
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**[[1hyl]], [[2hlc]] – Col – ''Hypoderma lineatum''<br /> | **[[1hyl]], [[2hlc]] – Col – ''Hypoderma lineatum''<br /> | ||
**[[5sv5]] – Col C-terminal – ''Bacillus anthracis''<br /> | **[[5sv5]] – Col C-terminal – ''Bacillus anthracis''<br /> | ||
*Collagenase 3 or matrix metalloproteinase 13 see [[Matrix metalloproteinase]] | |||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 12:27, 14 May 2019
Collagenase (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the Matrix metalloproteinase family. RelevanceCol is used for therapy of wounds, Dupuytren's contracture and Peyronie's disease. Structural highlightsClostridium histolycum collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a , a and an .[1] Water molecules are shown as red spheres. .
3D Structures of collagenase
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3D Structures of collagenase3D Structures of collagenase
Updated on 14-May-2019
ReferencesReferences
- ↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548