6ajk: Difference between revisions

Revision as of 01:41, 6 June 2019

Crystal structure of TFB1M and h45 in homo sapiensCrystal structure of TFB1M and h45 in homo sapiens

Structural highlights

6ajk is a 2 chain structure with sequence from [1] and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[TFB1M_HUMAN] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.

Function

[TFB1M_HUMAN] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.^[1] ^[2] ^[3]

References

↑ McCulloch V, Seidel-Rogol BL, Shadel GS. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol. 2002 Feb;22(4):1116-25. PMID:11809803
↑ Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet. 2002 Jul;31(3):289-94. Epub 2002 Jun 17. PMID:12068295 doi:http://dx.doi.org/10.1038/ng909
↑ McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol. 2003 Aug;23(16):5816-24. PMID:12897151

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OCA

[1] McCulloch V, Seidel-Rogol BL, Shadel GS. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. Mol Cell Biol. 2002 Feb;22(4):1116-25. PMID:11809803

[2] Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. Nat Genet. 2002 Jul;31(3):289-94. Epub 2002 Jun 17. PMID:12068295 doi:http://dx.doi.org/10.1038/ng909

[3] McCulloch V, Shadel GS. Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. Mol Cell Biol. 2003 Aug;23(16):5816-24. PMID:12897151

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6ajk is ON HOLD  until Paper Publication
+==Crystal structure of TFB1M and h45 in homo sapiens==
+<StructureSection load='6ajk' size='340' side='right'caption='[[6ajk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors: Liu, X., Shen, S., Wu, P., Li, F., Wang, C., Gong, Q., Wu, J., Zhang, H., Shi, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6ajk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJK FirstGlance]. <br>
-Description: Crystal structure of TFB1M and h45 in homo sapiens
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ajk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajk OCA], [http://pdbe.org/6ajk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ajk RCSB], [http://www.ebi.ac.uk/pdbsum/6ajk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajk ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Wu, J]]
+== Disease ==
-[[Category: Zhang, H]]
+[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] Mitochondrial non-syndromic sensorineural deafness. Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by the A1555G mutation in the mitochondrial 12S rRNA.
+== Function ==
+[[http://www.uniprot.org/uniprot/TFB1M_HUMAN TFB1M_HUMAN]] S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.<ref>PMID:11809803</ref> <ref>PMID:12068295</ref> <ref>PMID:12897151</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gong, Q]]
+[[Category: Li, F]]
 [[Category: Liu, X]]
-[[Category: Gong, Q]]
+[[Category: Shen, S]]
+[[Category: Shi, Y]]
 [[Category: Wang, C]]
+[[Category: Wu, J]]
 [[Category: Wu, P]]
-[[Category: Shen, S]]
+[[Category: Zhang, H]]
-[[Category: Li, F]]
+[[Category: Helix45]]
-[[Category: Shi, Y]]
+[[Category: Tfb1m]]
+[[Category: Transferase-rna complex]]

6ajk: Difference between revisions

Revision as of 01:41, 6 June 2019

Crystal structure of TFB1M and h45 in homo sapiensCrystal structure of TFB1M and h45 in homo sapiens

Structural highlights

Disease

Function

References

Contents

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6ajk: Difference between revisions

Revision as of 01:41, 6 June 2019

Crystal structure of TFB1M and h45 in homo sapiensCrystal structure of TFB1M and h45 in homo sapiens

Structural highlights

Disease

Function

References

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