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==Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A== | ==Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A== | ||
<StructureSection load='3mvg' size='340' side='right' caption='[[3mvg]], [[Resolution|resolution]] 1.25Å' scene=''> | <StructureSection load='3mvg' size='340' side='right'caption='[[3mvg]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3mvg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Iris_hollandica Iris hollandica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVG OCA]. For a <b>guided tour on the structure components</b> use [http:// | <table><tr><td colspan='2'>[[3mvg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Iris_hollandica Iris hollandica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MVG FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b7u|2b7u]], [[1bry|1bry]], [[1ahc|1ahc]], [[1nio|1nio]], [[1rl0|1rl0]], [[2oqa|2oqa]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b7u|2b7u]], [[1bry|1bry]], [[1ahc|1ahc]], [[1nio|1nio]], [[1rl0|1rl0]], [[2oqa|2oqa]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mvg OCA], [http://pdbe.org/3mvg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mvg RCSB], [http://www.ebi.ac.uk/pdbsum/3mvg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mvg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Iris hollandica]] | [[Category: Iris hollandica]] | ||
[[Category: Large Structures]] | |||
[[Category: RRNA N-glycosylase]] | [[Category: RRNA N-glycosylase]] | ||
[[Category: Betzel, C]] | [[Category: Betzel, C]] | ||
Revision as of 11:59, 21 October 2020
Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 ANative structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A
Structural highlights
Publication Abstract from PubMedThe most abundant protein of Iris bulbs has been identified as a type 1 ribosome-inactivating protein (RIP). Analysis of the purified proteins and molecular cloning of the corresponding cDNAs demonstrated that this type 1 RIP is a mixture of three isoforms that exhibit a high degree of sequence identity and have similar, though not identical, ribosome-inactivating and polynucleotide:adenosine glycosidase activities. The accumulation of large quantities of type 1 RIP in a vegetative storage organ suggests that this presumed defence-related protein also plays a role in the nitrogen-storage metabolism of the bulb. Type 1 ribosome-inactivating proteins are the most abundant proteins in iris (Iris hollandica var. Professor Blaauw) bulbs: characterization and molecular cloning.,Van Damme EJ, Barre A, Barbieri L, Valbonesi P, Rouge P, Van Leuven F, Stirpe F, Peumans WJ Biochem J. 1997 Jun 15;324 ( Pt 3):963-70. PMID:9210423[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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