Ferredoxin NADP+ Reductase: Difference between revisions
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<StructureSection load='4FK8' size='340' frame='true' side='right' caption='FNR protein containg FAD (PDB code [[4fk8]])' scene=''> | <StructureSection load='4FK8' size='340' frame='true' side='right' caption='FNR protein containg FAD (PDB code [[4fk8]])' scene=''> | ||
==Function== | |||
'''Ferredoxin NADP<sup>+</sup> reductase''' [http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] is an enzyme that catalyzes the reduction of NADP<sup>+</sup> to NADPH. This enzyme belongs to a family of enzymes called oxidoreductases[http://en.wikipedia.org/wiki/Oxidoreductase] that contain iron-sulfur proteins as electron donors and NAD<sup>+</sup> or NADP<sup>+</sup> as electron acceptors. FAD, [flavin adenine dinucleotide][http://en.wikipedia.org/wiki/Flavin_adenine_dinucleotide], is also a cofactor of FNR. The ferredoxin NADP<sup>+</sup> reductase participates in a general reaction that proceeds as follows: | '''Ferredoxin NADP<sup>+</sup> reductase''' [http://en.wikipedia.org/wiki/Ferredoxin—NADP(%2B)_reductase] is an enzyme that catalyzes the reduction of NADP<sup>+</sup> to NADPH. This enzyme belongs to a family of enzymes called oxidoreductases[http://en.wikipedia.org/wiki/Oxidoreductase] that contain iron-sulfur proteins as electron donors and NAD<sup>+</sup> or NADP<sup>+</sup> as electron acceptors. FAD, [flavin adenine dinucleotide][http://en.wikipedia.org/wiki/Flavin_adenine_dinucleotide], is also a cofactor of FNR. The ferredoxin NADP<sup>+</sup> reductase participates in a general reaction that proceeds as follows: | ||
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In its active form, the protein is a <scene name='69/699901/Dimeric_fnr/1'>dimer</scene> and contains a [4Fe-4S]<sup>+2</sup> cluster. When inactive, the protein is monomeric and containts a [3Fe-4S]<sup>+2</sup> cluster. FNR in its <scene name='69/699901/Monomeric_fnr/1'>monomer</scene> form can be seen here, with bound NADP and FAD.<ref> PMID: 21166900 </ref> | In its active form, the protein is a <scene name='69/699901/Dimeric_fnr/1'>dimer</scene> and contains a [4Fe-4S]<sup>+2</sup> cluster. When inactive, the protein is monomeric and containts a [3Fe-4S]<sup>+2</sup> cluster. FNR in its <scene name='69/699901/Monomeric_fnr/1'>monomer</scene> form can be seen here, with bound NADP and FAD.<ref> PMID: 21166900 </ref> | ||
== 3D Structures of Ferredoxin NADP+ reductase == | |||
[[Ferredoxin NADP+ reductase 3D structure]] | |||
</StructureSection> | </StructureSection> | ||
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**[[3lo8]], [[3lvb]], [[1jb9]], [[1gaw]] – mFNR + FAD <br /> | **[[3lo8]], [[3lvb]], [[1jb9]], [[1gaw]] – mFNR + FAD <br /> | ||
**[[5vw4]], [[5vw5]], [[5vw9]] - mFNR (mutant) + nicotinamide + FAD <br /> | **[[5vw4]], [[5vw5]], [[5vw9]] - mFNR (mutant) + nicotinamide + FAD <br /> | ||
**[[5zbv]], [[5twb]], [[5twc]] – FNR + FAD – ''Staphylococcus aureus''<br /> | **[[5zbv]], [[5twb]], [[5twc]], [[6a4j]] – FNR + FAD – ''Staphylococcus aureus''<br /> | ||
**[[5xhu]] – BsFNR + FAD <br /> | **[[5xhu]] – BsFNR + FAD <br /> | ||
**[[6gar]], [[6gas]] – FNR + FAD – ''Bacillus cereus''<br /> | |||
**[[5ygq]] – FNR + FAD – ''Rhodopseudomonas palustris''<br /> | |||
**[[5h59]] - mFNR + FAD <br /> | **[[5h59]] - mFNR + FAD <br /> | ||
**[[5vwa]] - mFNR (mutant) + FAD <br /> | **[[5vwa]] - mFNR (mutant) + FAD <br /> | ||