Sandbox Reserved 1489: Difference between revisions
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The binding of the substrate in the binding site leads to a switch from the outward-facing open state to the outward-facing occluded state. The TM10 arrangement changes (''Figure 4.C'') and closes the access to the “OUT” side space of the membrane (''Figure 5.A''). | The binding of the substrate in the binding site leads to a switch from the outward-facing open state (2JLN) to the outward-facing occluded state [[4D1B]]. The TM10 arrangement changes (''Figure 4.C'') and closes the access to the “OUT” side space of the membrane (''Figure 5.A''). | ||
Then, there is a change from the outward-facing occluded state to the inward-facing occluded state. (''Figure 5.B'') The substrate-binding site is occluded from the inside of the membrane. It seems that the movement involves the helix bundle of TMs 3 and 8. Moreover, researchers are working on the possibility of a coordinated shifting of TMs 1 and 6 shift with TMs 3 and 8. | Then, there is a change from the outward-facing occluded state to the inward-facing occluded state [[4D1A]]. (''Figure 5.B'') The substrate-binding site is occluded from the inside of the membrane. It seems that the movement involves the helix bundle of TMs 3 and 8. Moreover, researchers are working on the possibility of a coordinated shifting of TMs 1 and 6 shift with TMs 3 and 8. | ||
Eventually, there is a switch from the inward-facing occluded state to the inward-facing open state. This allows the release of the substrate in the cytoplasm. However, the structures involved in the change still be unclear (''Figure 5.C''). | Eventually, there is a switch from the inward-facing occluded state to the inward-facing open state [[2X79]]. This allows the release of the substrate in the cytoplasm. However, the structures involved in the change still be unclear (''Figure 5.C''). | ||
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== References == | == References == | ||
<references/> | <references/> | ||