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== Interaction with LEDGF/p75 and antiviral ==
== Reserach on antiviral ==


Research on HIV show that the integrase use a protein, the LEDGF/p75 cofactor, so as to the preintegration complex is ligated to the DNA.  
Research on HIV show that the integrase use a protein, the LEDGF/p75 cofactor, so as to the preintegration complex is ligated to the DNA.  
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====Structure and role of the core domain in the integration====
====Structure and role of the core domain in the integration====
'''The three domain of the HIV integrase:'''


[[Image:Domain_HIV_Integrase.jpg]]
[[Image:Domain_HIV_Integrase.jpg]]
'''HIV Integrase sequence:'''
[[Image:HIV_Integrase_sequenc.jpg]]


[[Image:HIV Integrase sequence.jpg]]
[[Image:HIV Integrase sequence.jpg]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA, Severine Perrin