Sandbox Reserved 1489: Difference between revisions

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 Mhp1 is a trans-membrane protein bellowing to the nucleobase-cation-symport-1 (NCS1) transporter family from Microbacterium liquefaciens.
-A secondary transporter, like Mhp1, effects the cellular uptake and release of a wide range of substances across biological membranes in all organisms. This is done by coupling the uphill movement of the substrate against its concentration gradient with the energetically favorable downhill gradient of a second substrate, often a proton or a cation. The kinetics and thermodynamics of the transporters can be explained by their alternating conformations.[doi: 10.1126/science.1186303]
+A secondary transporter, like Mhp1, effects the cellular uptake and release of a wide range of substances across biological membranes in all organisms. This is done by coupling the uphill movement of the substrate against its concentration gradient with the energetically favorable downhill gradient of a second substrate, often a proton or a cation. The kinetics and thermodynamics of the transporters can be explained by their alternating conformations.<ref>DOI 10.1126/science</ref>      .1186303]
 In the case of Mhp1, it allows the sodium dependent income of indolyl methyl- and benzyl-hydantoins (''Figure 1'') in the cell. Those are part of a salvage metabolic pathway leading to their conversion in amino acids.