Sandbox Reserved 1502: Difference between revisions
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=='''3lpt - HIV integrase'''== | =='''3lpt - HIV integrase'''== | ||
<StructureSection load='3lpt' size='340' side='right' caption='[[3lpt]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3lpt' size='340' side='right' caption='[[3lpt]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
3lt is an integrase of the HIV, the Human Immunodeficiency Virus. An integrase is an enzyme produced by a retrovirus to integrate its genetic material into the DNA of the infected cell. | 3lt is an integrase of the HIV, the Human Immunodeficiency Virus. An integrase is an enzyme produced by a retrovirus to integrate its genetic material into the DNA of the infected cell. It is one of three enzymes of HIV, the others being the Reverse Transcriptase and the Protease. | ||
== Structural highlights == | == Structural highlights == | ||
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== Function == | == Function == | ||
HIV integrase is an enzyme required for the integration of viral DNA into the host genome. The process of integration can be divided into two sequential reactions. In the first one, named 3'-processing, the enzyme removes di- or trinucleotides from viral DNA ends to expose 3′-hydroxyls attached to the invariant CA dinucleotides. The second step is the insertion of the processed 3′-viral DNA ends into the host chromosomal DNA by a trans-esterification reaction. This is the strand transfer. | |||
== Structure == | == Structure == | ||
[[Image:HIV Integrase sequence.jpg]] | [[Image:HIV Integrase sequence.jpg]] | ||