3ly5: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 1: Line 1:


==DDX18 dead-domain==
==DDX18 dead-domain==
<StructureSection load='3ly5' size='340' side='right' caption='[[3ly5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3ly5' size='340' side='right'caption='[[3ly5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ly5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LY5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LY5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ly5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LY5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LY5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDX18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ly5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ly5 OCA], [http://pdbe.org/3ly5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ly5 RCSB], [http://www.ebi.ac.uk/pdbsum/3ly5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ly5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ly5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ly5 OCA], [https://pdbe.org/3ly5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ly5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ly5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ly5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DDX18_HUMAN DDX18_HUMAN]] Probable RNA-dependent helicase.  
[https://www.uniprot.org/uniprot/DDX18_HUMAN DDX18_HUMAN] Probable RNA-dependent helicase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 20: Line 20:
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ly5 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ly5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domains that both contribute to RNA and ATP binding. Despite recent advances the molecular details of how these enzymes convert chemical energy into RNA remodeling is unknown. We present crystal structures of the isolated DEAD-domains of human DDX2A/eIF4A1, DDX2B/eIF4A2, DDX5, DDX10/DBP4, DDX18/myc-regulated DEAD-box protein, DDX20, DDX47, DDX52/ROK1, and DDX53/CAGE, and of the helicase domains of DDX25 and DDX41. Together with prior knowledge this enables a family-wide comparative structural analysis. We propose a general mechanism for opening of the RNA binding site. This analysis also provides insights into the diversity of DExD/H- proteins, with implications for understanding the functions of individual family members.
Comparative structural analysis of human DEAD-box RNA helicases.,Schutz P, Karlberg T, van den Berg S, Collins R, Lehtio L, Hogbom M, Holmberg-Schiavone L, Tempel W, Park HW, Hammarstrom M, Moche M, Thorsell AG, Schuler H PLoS One. 2010 Sep 30;5(9). pii: e12791. PMID:20941364<ref>PMID:20941364</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ly5" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Helicase|Helicase]]
*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Berg, S Van Den]]
[[Category: Arrowsmith CH]]
[[Category: Berglund, H]]
[[Category: Berglund H]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Collins, R]]
[[Category: Collins R]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Flodin, S]]
[[Category: Flodin S]]
[[Category: Flores, A]]
[[Category: Flores A]]
[[Category: Graslund, S]]
[[Category: Graslund S]]
[[Category: Hammarstrom, M]]
[[Category: Hammarstrom M]]
[[Category: Johansson, A]]
[[Category: Johansson A]]
[[Category: Johansson, I]]
[[Category: Johansson I]]
[[Category: Kallas, A]]
[[Category: Kallas A]]
[[Category: Karlberg, T]]
[[Category: Karlberg T]]
[[Category: Kotenyova, T]]
[[Category: Kotenyova T]]
[[Category: Kotzsch, A]]
[[Category: Kotzsch A]]
[[Category: Kraulis, P]]
[[Category: Kraulis P]]
[[Category: Markova, N]]
[[Category: Markova N]]
[[Category: Moche, M]]
[[Category: Moche M]]
[[Category: Nielsen, T K]]
[[Category: Nielsen TK]]
[[Category: Nordlund, P]]
[[Category: Nordlund P]]
[[Category: Nyman, T]]
[[Category: Nyman T]]
[[Category: Persson, C]]
[[Category: Persson C]]
[[Category: Roos, A K]]
[[Category: Roos AK]]
[[Category: Structural genomic]]
[[Category: Schuler HM]]
[[Category: Schuler, H M]]
[[Category: Schutz P]]
[[Category: Schutz, P]]
[[Category: Siponen MI]]
[[Category: Siponen, M I]]
[[Category: Svensson L]]
[[Category: Svensson, L]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L]]
[[Category: Van Den Berg S]]
[[Category: Wahlberg, E]]
[[Category: Wahlberg E]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Welin, M]]
[[Category: Welin M]]
[[Category: Wisniewska, M]]
[[Category: Wisniewska M]]
[[Category: Alpha-beta]]
[[Category: Atp-binding]]
[[Category: Helicase]]
[[Category: Hydrolase]]
[[Category: Nucleotide-binding]]
[[Category: Rna-binding]]
[[Category: Sgc]]

Latest revision as of 13:22, 21 February 2024

DDX18 dead-domainDDX18 dead-domain

Structural highlights

3ly5 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DDX18_HUMAN Probable RNA-dependent helicase.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3ly5, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=3ly5&oldid=4066444"