3jwe: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of human mono-glyceride lipase in complex with SAR629== | ==Crystal structure of human mono-glyceride lipase in complex with SAR629== | ||
<StructureSection load='3jwe' size='340' side='right' caption='[[3jwe]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='3jwe' size='340' side='right'caption='[[3jwe]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3jwe]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JWE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F4P:1-[BIS(4-FLUOROPHENYL)METHYL]-4-(1H-1,2,4-TRIAZOL-1-YLCARBONYL)PIPERAZINE'>F4P</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwe OCA], [https://pdbe.org/3jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jwe RCSB], [https://www.ebi.ac.uk/pdbsum/3jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwe ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Lipase|Lipase]] | *[[Lipase 3D Structures|Lipase 3D Structures]] | ||
*[[Sandbox reserved 916|Sandbox reserved 916]] | *[[Sandbox reserved 916|Sandbox reserved 916]] | ||
== References == | == References == | ||
| Line 38: | Line 37: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Auge | [[Category: Auge F]] | ||
[[Category: Berne | [[Category: Berne PF]] | ||
[[Category: Bertrand | [[Category: Bertrand T]] | ||
[[Category: Cheuret | [[Category: Cheuret D]] | ||
[[Category: Hoornaert | [[Category: Hoornaert C]] | ||
[[Category: Houtmann | [[Category: Houtmann J]] | ||
[[Category: Mathieu | [[Category: Mathieu M]] | ||
[[Category: Michot | [[Category: Michot N]] | ||
[[Category: Mikol | [[Category: Mikol V]] | ||
[[Category: Rak | [[Category: Rak A]] | ||
[[Category: Vallee | [[Category: Vallee F]] | ||