3ii7: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==Crystal structure of the kelch domain of human KLHL7== | ==Crystal structure of the kelch domain of human KLHL7== | ||
<StructureSection load='3ii7' size='340' side='right' caption='[[3ii7]], [[Resolution|resolution]] 1.63Å' scene=''> | <StructureSection load='3ii7' size='340' side='right'caption='[[3ii7]], [[Resolution|resolution]] 1.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ii7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ii7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLHL7 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLHL7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii7 OCA], [https://pdbe.org/3ii7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[[ | [[https://www.uniprot.org/uniprot/KLHL7_HUMAN KLHL7_HUMAN]] Retinitis pigmentosa. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/KLHL7_HUMAN KLHL7_HUMAN]] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.<ref>PMID:21828050</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Line 33: | Line 33: | ||
==See Also== | ==See Also== | ||
*[[Kelch-like protein|Kelch-like protein]] | *[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Line 39: | Line 39: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] |