3bt1: Difference between revisions

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 [[Image:3bt1.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 3bt1 |SIZE=350|CAPTION= <scene name='initialview01'>3bt1</scene>, resolution 2.80&Aring;
+The line below this paragraph, containing "STRUCTURE_3bt1", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+U+1052'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+U+1172'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+U+1200'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+U+1201'>AC4</scene> and <scene name='pdbsite=AC5:Man+Binding+Site+For+Residue+U+1202'>AC5</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VTN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PLAUR, MO3, UPAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00108 KR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00117 LU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00134 LU], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01033 Somatomedin_B]</span>
+{{STRUCTURE_3bt1|  PDB=3bt1  |  SCENE=  }}
-|RELATEDENTRY=[[2fd6|2fd6]], [[3bt2|3BT2]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bt1 OCA], [http://www.ebi.ac.uk/pdbsum/3bt1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bt1 RCSB]</span>
-}}
 '''Structure of urokinase receptor, urokinase and vitronectin complex'''
+==Overview==
+The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
 ==Disease==
@@ Line 20: / Line 20: @@
 ==About this Structure==
 BT1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BT1 OCA].
+==Reference==
+Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes., Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M, Nat Struct Mol Biol. 2008 Apr;15(4):422-3. Epub 2008 Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18376415 18376415]
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
 [[Category: Huang, M.]]
-[[Category: alternative splicing]]
+[[Category: Alternative splicing]]
-[[Category: blood coagulation]]
+[[Category: Blood coagulation]]
-[[Category: cell adhesion]]
+[[Category: Cell adhesion]]
-[[Category: egf-like domain]]
+[[Category: Egf-like domain]]
-[[Category: fibrinolysis]]
+[[Category: Fibrinolysis]]
-[[Category: glycoprotein]]
+[[Category: Glycoprotein]]
-[[Category: gpi-anchor]]
+[[Category: Gpi-anchor]]
-[[Category: heparin-binding]]
+[[Category: Heparin-binding]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: immune system]]
+[[Category: Immune system]]
-[[Category: immunoglobulin domain]]
+[[Category: Immunoglobulin domain]]
-[[Category: kringle]]
+[[Category: Kringle]]
-[[Category: lipoprotein]]
+[[Category: Lipoprotein]]
-[[Category: membrane]]
+[[Category: Membrane]]
-[[Category: pharmaceutical]]
+[[Category: Pharmaceutical]]
-[[Category: phosphoprotein]]
+[[Category: Phosphoprotein]]
-[[Category: plasminogen activation]]
+[[Category: Plasminogen activation]]
-[[Category: polymorphism]]
+[[Category: Polymorphism]]
-[[Category: protease]]
+[[Category: Protease]]
-[[Category: protein-protein complex]]
+[[Category: Protein-protein complex]]
-[[Category: receptor]]
+[[Category: Receptor]]
-[[Category: secreted]]
+[[Category: Secreted]]
-[[Category: serine protease]]
+[[Category: Serine protease]]
-[[Category: sulfation]]
+[[Category: Sulfation]]
-[[Category: zymogen]]
+[[Category: Zymogen]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 24 09:33:44 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:28:41 2008''