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OCA, Christina R. Bourne, Zhaihui G. Modlin

Revision as of 21:07, 14 December 2018 view source Zhaihui G. Modlin (talk \| contribs) 255 edits No edit summary ← Older edit		Revision as of 21:24, 14 December 2018 view source Zhaihui G. Modlin (talk \| contribs) 255 edits No edit summary Newer edit →
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	mAb4G9, attributing to the design of hapten (+)METH MO10<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>, was the only<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/> mAb to significantly cross-react with (+)AMP. In order to better understand its affinity for AMP, RIA analysis using [(+)-3H]AMP was conducted in addition to RIA analysis using [(+)-3H]METH<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>. It was reported, the affinity for mAb4G9 for AMP is 51nM<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>, demonstrating this molecule actually has the same KD value for (+)AMP and (+)METH<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>.		mAb4G9, attributing to the design of hapten (+)METH MO10<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>, was the only<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/> mAb to significantly cross-react with (+)AMP. In order to better understand its affinity for AMP, RIA analysis using [(+)-3H]AMP was conducted in addition to RIA analysis using [(+)-3H]METH<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>. It was reported, the affinity for mAb4G9 for AMP is 51nM<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>, demonstrating this molecule actually has the same KD value for (+)AMP and (+)METH<ref name="Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse"/>.

			[[Image:Affinity of mAbs for stimulants]]