3b9q: Difference between revisions

Revision as of 20:33, 4 May 2008

The crystal structure of cpFtsY from Arabidopsis thaliana

OverviewOverview

Two GTPases in the signal recognition particle and its receptor (FtsY) regulate protein targeting to the membrane by formation of a heterodimeric complex. The activation of both GTPases in the complex is essential for protein translocation. We present the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution. The comparison with FtsY structures in different nucleotide bound states shows structural changes relevant for GTPase activation and provides insights in how cpFtsY is pre-organized for complex formation with cpSRP54. The structure contains an amino-terminal amphipathic helix similar to the membrane targeting sequence of Escherichia coli FtsY. In cpFtsY this motif is extended, which might be responsible for the enhanced attachment of the protein to the thylakoid membrane.

About this StructureAbout this Structure

3B9Q is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site., Stengel KF, Holdermann I, Wild K, Sinning I, FEBS Lett. 2007 Dec 11;581(29):5671-6. Epub 2007 Nov 20. PMID:18022392 Page seeded by OCA on Sun May 4 20:33:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:3b9q.jpg|left|200px]]
- {{Structure
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-}}
 '''The crystal structure of cpFtsY from Arabidopsis thaliana'''
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 [[Category: Stengel, K F.]]
 [[Category: Wild, K.]]
-[[Category: cpftsy]]
+[[Category: Cpftsy]]
-[[Category: gtp-binding]]
+[[Category: Gtp-binding]]
-[[Category: nucleotide-binding]]
+[[Category: Nucleotide-binding]]
-[[Category: protein translocation]]
+[[Category: Protein translocation]]
-[[Category: protein transport]]
+[[Category: Protein transport]]
-[[Category: srp receptor]]
+[[Category: Srp receptor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:33:20 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:24:25 2008''