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==Crystal structure of the complete turnip yellow mosaic virus 3'UTR== | |||
<StructureSection load='6mj0' size='340' side='right' caption='[[6mj0]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mj0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MJ0 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mj0 OCA], [http://pdbe.org/6mj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mj0 RCSB], [http://www.ebi.ac.uk/pdbsum/6mj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mj0 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Structured RNA elements, programmed RNA conformational changes, and interactions between different RNA domains underlie many modes of regulating gene expression, mandating studies to understand the foundational principles that govern these phenomena. Exploring the structured 3' untranslated region (UTR) of a viral RNA, we discovered that different contexts of the 3'-UTR confer different abilities to enhance translation of an associated open reading frame. In one context, ribosome-induced conformational changes in a 'sensor' RNA domain affect a separate RNA 'functional' domain, altering translation efficiency. The structure of the entire 3'-UTR reveals that structurally distinct domains use a spine of continuously stacked bases and a strut-like linker to create a conduit for communication within the higher-order architecture. Thus, this 3'-UTR RNA illustrates how RNA can use programmed conformational changes to sense the translation status of an upstream open reading frame, then create a tuned functional response by communicating that information to other RNA elements. | |||
Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels.,Hartwick EW, Costantino DA, MacFadden A, Nix JC, Tian S, Das R, Kieft JS Nat Commun. 2018 Nov 29;9(1):5074. doi: 10.1038/s41467-018-07542-x. PMID:30498211<ref>PMID:30498211</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6mj0" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Costantino, D A]] | |||
[[Category: Das, R]] | |||
[[Category: Hartwick, E W]] | |||
[[Category: Kieft, J S]] | |||
[[Category: MacFadden, A]] | |||
[[Category: Nix, J C]] | |||
[[Category: Tian, S]] | |||
[[Category: Programmed conformational change]] | |||
[[Category: Rna]] | |||
[[Category: Translation enhancer]] | |||
[[Category: Trna like-structure]] | |||
[[Category: Trna mimicry]] | |||