2za3: Difference between revisions

Revision as of 20:05, 4 May 2008

Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with uridine 5'-monophosphate from P.falciparum

OverviewOverview

Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we report the X-ray analysis of apo, substrate or product-complex forms of OMPDC from Plasmodium falciparum (PfOMPDC) at 2.7, 2.65 and 2.65 A, respectively. The structural analysis provides the substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site. The structural basis of substrate or product binding to PfOMPDC will help to uncover the decarboxylation mechanism and facilitate structure-based optimization of antimalarial drugs.

About this StructureAbout this Structure

2ZA3 is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

ReferenceReference

Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:17981823 Page seeded by OCA on Sun May 4 20:05:12 2008

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OCA

@@ Line 1: / Line 1: @@
 [[Image:2za3.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2za3 |SIZE=350|CAPTION= <scene name='initialview01'>2za3</scene>, resolution 2.65&Aring;
+The line below this paragraph, containing "STRUCTURE_2za3", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:U5p+Binding+Site+For+Residue+A+500'>AC1</scene> and <scene name='pdbsite=AC2:U5p+Binding+Site+For+Residue+B+600'>AC2</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=U5P:URIDINE-5&#39;-MONOPHOSPHATE'>U5P</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2za3|  PDB=2za3  |  SCENE=  }}
-|RELATEDENTRY=[[2f84|2F84]], [[2za1|2ZA1]], [[2za2|2ZA2]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2za3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2za3 OCA], [http://www.ebi.ac.uk/pdbsum/2za3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2za3 RCSB]</span>
-}}
 '''Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with uridine 5'-monophosphate from P.falciparum'''
@@ Line 28: / Line 25: @@
 [[Category: Inoue, T.]]
 [[Category: Tokuoka, K.]]
-[[Category: lyase]]
+[[Category: Lyase]]
-[[Category: orotidine 5'-monophosphate decarboxylase]]
+[[Category: Orotidine 5'-monophosphate decarboxylase]]
-[[Category: plasmodium falciparum]]
+[[Category: Plasmodium falciparum]]
-[[Category: pyrimidine biosynthesis]]
+[[Category: Pyrimidine biosynthesis]]
-[[Category: uridine 5'-monophosphate]]
+[[Category: Uridine 5'-monophosphate]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:05:12 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:51 2008''