3e73: Difference between revisions
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==Crystal Structure of Human LanCL1 complexed with GSH== | ==Crystal Structure of Human LanCL1 complexed with GSH== | ||
<StructureSection load='3e73' size='340' side='right' caption='[[3e73]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='3e73' size='340' side='right'caption='[[3e73]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3e73]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3e73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E73 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3e6u|3e6u]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3e6u|3e6u]]</div></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LANCL1 ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LANCL1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e73 OCA], [https://pdbe.org/3e73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e73 RCSB], [https://www.ebi.ac.uk/pdbsum/3e73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e73 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/LANC1_HUMAN LANC1_HUMAN]] May play a role in EPS8 signaling. Binds glutathion.<ref>PMID:19528316</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 35: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Li, X]] | [[Category: Li, X]] | ||
[[Category: Rao, Z]] | [[Category: Rao, Z]] | ||
Revision as of 14:41, 16 February 2022
Crystal Structure of Human LanCL1 complexed with GSHCrystal Structure of Human LanCL1 complexed with GSH
Structural highlights
Function[LANC1_HUMAN] May play a role in EPS8 signaling. Binds glutathion.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedEukaryotic lanthionine synthetase C-like protein 1 (LanCL1) is homologous to prokaryotic lanthionine cyclases, yet its biochemical functions remain elusive. We report the crystal structures of human LanCL1, both free of and complexed with glutathione, revealing glutathione binding to a zinc ion at the putative active site formed by conserved GxxG motifs. We also demonstrate by in vitro affinity analysis that LanCL1 binds specifically to the SH3 domain of a signaling protein, Eps8. Importantly, expression of LanCL1 mutants defective in Eps8 interaction inhibits nerve growth factor (NGF)-induced neurite outgrowth, providing evidence for the biological significance of this novel interaction in cellular signaling and differentiation. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.,Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z, Zhang XC Genes Dev. 2009 Jun 15;23(12):1387-92. PMID:19528316[2] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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