2z4f: Difference between revisions

Revision as of 19:56, 4 May 2008

Solution structure of the Discoidin Domain of DDR2

OverviewOverview

Discoidin domain receptor (DDR) is a cell-surface receptor tyrosine kinase activated by the binding of its discoidin (DS) domain to fibrillar collagen. Here, we have determined the NMR structure of the DS domain in DDR2 (DDR2-DS domain), and identified the binding site to fibrillar collagen by transferred cross-saturation experiments. The DDR2-DS domain structure adopts a distorted jellyroll fold, consisting of eight beta-strands. The collagen-binding site is formed at the interloop trench, consisting of charged residues surrounded by hydrophobic residues. The surface profile of the collagen-binding site suggests that the DDR2-DS domain recognizes specific sites on fibrillar collagen. This study provides a molecular basis for the collagen-binding mode of the DDR2-DS domain.

About this StructureAbout this Structure

2Z4F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural basis of the collagen-binding mode of discoidin domain receptor 2., Ichikawa O, Osawa M, Nishida N, Goshima N, Nomura N, Shimada I, EMBO J. 2007 Sep 19;26(18):4168-76. Epub 2007 Aug 16. PMID:17703188 Page seeded by OCA on Sun May 4 19:56:24 2008

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OCA

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 [[Image:2z4f.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 2z4f |SIZE=350|CAPTION= <scene name='initialview01'>2z4f</scene>
+The line below this paragraph, containing "STRUCTURE_2z4f", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND=
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE= DDR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+-->
-|DOMAIN=
+{{STRUCTURE_2z4f|  PDB=2z4f  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z4f OCA], [http://www.ebi.ac.uk/pdbsum/2z4f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z4f RCSB]</span>
-}}
 '''Solution structure of the Discoidin Domain of DDR2'''
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 [[Category: Osawa, M.]]
 [[Category: Shimada, I.]]
-[[Category: beta barrel]]
+[[Category: Beta barrel]]
-[[Category: transferase]]
+[[Category: Transferase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:56:24 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:18:28 2008''