3edi: Difference between revisions

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==Crystal structure of tolloid-like protease 1 (TLL-1) protease domain==
==Crystal structure of tolloid-like protease 1 (TLL-1) protease domain==
<StructureSection load='3edi' size='340' side='right' caption='[[3edi]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='3edi' size='340' side='right'caption='[[3edi]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3edi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EDI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3edi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EDI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3edg|3edg]], [[3edh|3edh]], [[1dle|1dle]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3edg|3edg]], [[3edh|3edh]], [[1dle|1dle]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLL1, TLL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLL1, TLL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edi OCA], [http://pdbe.org/3edi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3edi RCSB], [http://www.ebi.ac.uk/pdbsum/3edi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3edi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3edi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3edi OCA], [https://pdbe.org/3edi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3edi RCSB], [https://www.ebi.ac.uk/pdbsum/3edi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3edi ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:[http://omim.org/entry/613087 613087]]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.<ref>PMID:18830233</ref>   
[[https://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Defects in TLL1 are the cause of atrial septal defect type 6 (ASD6) [MIM:[https://omim.org/entry/613087 613087]]. A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.<ref>PMID:18830233</ref>   
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.  
[[https://www.uniprot.org/uniprot/TLL1_HUMAN TLL1_HUMAN]] Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Sweeney, A Mac]]
[[Category: Sweeney, A Mac]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]

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