Syntaxin: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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<StructureSection load='3ipd' size='340' side='right' caption=' | <StructureSection load='3ipd' size='340' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (grey) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene=''> | ||
== Function == | == Function == | ||
'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>. | '''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. | |||
</StructureSection> | </StructureSection> | ||