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==The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type (CASP Target)==
==The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type==
<StructureSection load='3d3l' size='340' side='right' caption='[[3d3l]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3d3l' size='340' side='right'caption='[[3d3l]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3d3l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D3L FirstGlance]. <br>
<table><tr><td colspan='2'>[[3d3l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D3L FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALOX12, LOG12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALOX12, LOG12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arachidonate_12-lipoxygenase Arachidonate 12-lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.31 1.13.11.31] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arachidonate_12-lipoxygenase Arachidonate 12-lipoxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.31 1.13.11.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d3l OCA], [http://pdbe.org/3d3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3d3l RCSB], [http://www.ebi.ac.uk/pdbsum/3d3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3d3l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d3l OCA], [https://pdbe.org/3d3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d3l RCSB], [https://www.ebi.ac.uk/pdbsum/3d3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d3l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LOX12_HUMAN LOX12_HUMAN]] Oxygenase and 14,15-leukotriene A4 synthase activity.  
[[https://www.uniprot.org/uniprot/LOX12_HUMAN LOX12_HUMAN]] Oxygenase and 14,15-leukotriene A4 synthase activity.  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Arachidonate 12-lipoxygenase]]
[[Category: Arachidonate 12-lipoxygenase]]
[[Category: Human]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H]]
[[Category: Berg, S Van Den]]
[[Category: Berg, S Van Den]]

Revision as of 22:18, 20 October 2021

The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-typeThe 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type

Structural highlights

3d3l is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:ALOX12, LOG12 (HUMAN)
Activity:Arachidonate 12-lipoxygenase, with EC number 1.13.11.31
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LOX12_HUMAN] Oxygenase and 14,15-leukotriene A4 synthase activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3d3l, resolution 2.60Å

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