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| ==Crystal structure of a C-terminal phosphatase domain of Rattus norvegicus ortholog of human protein tyrosine phosphatase, receptor type, D (PTPRD)== | | ==Crystal structure of a C-terminal phosphatase domain of Rattus norvegicus ortholog of human protein tyrosine phosphatase, receptor type, D (PTPRD)== |
| <StructureSection load='2nv5' size='340' side='right' caption='[[2nv5]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='2nv5' size='340' side='right'caption='[[2nv5]]' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[2nv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NV5 FirstGlance]. <br> | | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NV5 FirstGlance]. <br> |
| </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPRD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr> | | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nv5 OCA], [https://pdbe.org/2nv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nv5 RCSB], [https://www.ebi.ac.uk/pdbsum/2nv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nv5 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2nv5 TOPSAN]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nv5 OCA], [http://pdbe.org/2nv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2nv5 RCSB], [http://www.ebi.ac.uk/pdbsum/2nv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2nv5 ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2nv5 TOPSAN]</span></td></tr> | |
| </table> | | </table> |
| == Evolutionary Conservation == | | == Evolutionary Conservation == |
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| </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nv5 ConSurf]. | | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nv5 ConSurf]. |
| <div style="clear:both"></div> | | <div style="clear:both"></div> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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| Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2nv5" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Tyrosine phosphatase|Tyrosine phosphatase]] | | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Buffalo rat]] | | [[Category: Large Structures]] |
| [[Category: Almo, S C]] | | [[Category: Almo SC]] |
| [[Category: Bain, K T]] | | [[Category: Bain KT]] |
| [[Category: Bonanno, J B]] | | [[Category: Bonanno JB]] |
| [[Category: Burley, S K]] | | [[Category: Burley SK]] |
| [[Category: Gilmore, J]] | | [[Category: Gilmore J]] |
| [[Category: Iizuka, M]] | | [[Category: Iizuka M]] |
| [[Category: Structural genomic]]
| | [[Category: Sauder JM]] |
| [[Category: Sauder, J M]] | | [[Category: Smith D]] |
| [[Category: Smith, D]] | | [[Category: Wasserman S]] |
| [[Category: Wasserman, S]] | | [[Category: Xu W]] |
| [[Category: Xu, W]] | |
| [[Category: Hydrolase]]
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| [[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
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| [[Category: Phosphatase]]
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| [[Category: PSI, Protein structure initiative]]
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