2vj5: Difference between revisions
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{{STRUCTURE_2vj5| PDB=2vj5 | SCENE= }} | |||
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'''SHIGELLA FLEXNERI MXIC''' | '''SHIGELLA FLEXNERI MXIC''' | ||
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[[Category: Lea, S M.]] | [[Category: Lea, S M.]] | ||
[[Category: Roversi, P.]] | [[Category: Roversi, P.]] | ||
[[Category: | [[Category: Mxic]] | ||
[[Category: | [[Category: Plasmid]] | ||
[[Category: | [[Category: Secretion regulation]] | ||
[[Category: | [[Category: Shigella flexneri]] | ||
[[Category: | [[Category: T3ss]] | ||
[[Category: | [[Category: Transport]] | ||
[[Category: | [[Category: Transport protein]] | ||
[[Category: | [[Category: Type three secretion system]] | ||
[[Category: | [[Category: Virulence]] | ||
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Revision as of 18:54, 4 May 2008
SHIGELLA FLEXNERI MXIC
OverviewOverview
Many Gram-negative pathogenic bacteria use a complex macromolecular machine, known as the type 3 secretion system (T3SS), to transfer virulence proteins into host cells. The T3SS is composed of a cytoplasmic bulb, a basal body spanning the inner and outer bacterial membranes, and an extracellular needle. Secretion is regulated by both cytoplasmic and inner membrane proteins that must respond to specific signals in order to ensure that virulence proteins are not secreted before contact with a eukaryotic cell. This negative regulation is mediated, in part, by a family of proteins that are thought to physically block the entrance to the secretion apparatus until an appropriate signal is received following host cell contact. Despite weak sequence homology between proteins of this family, the crystal structures of Shigella flexneri MxiC we present here confirm the conservation of domain topology with the homologue from Yersinia sp. Interestingly, comparison of the Shigella and Yersinia structures reveals a significant structural change that results in substantial domain re-arrangement and opening of one face of the molecule. The conservation of a negatively charged patch on this face suggests it may have a role in binding other components of the T3SS.
About this StructureAbout this Structure
2VJ5 is a Single protein structure of sequence from Shigella flexneri. Full crystallographic information is available from OCA.
ReferenceReference
Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues., Deane JE, Roversi P, King C, Johnson S, Lea SM, J Mol Biol. 2008 Feb 4;. PMID:18304577 Page seeded by OCA on Sun May 4 18:54:58 2008