2vex: Difference between revisions

Revision as of 18:41, 4 May 2008

CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR

OverviewOverview

The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.

About this StructureAbout this Structure

2VEX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines., Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW, Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. Epub 2007 Nov 9. PMID:18037290 Page seeded by OCA on Sun May 4 18:41:48 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:2vex.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 2vex |SIZE=350|CAPTION= <scene name='initialview01'>2vex</scene>, resolution 2.2&Aring;
+The line below this paragraph, containing "STRUCTURE_2vex", creates the "Structure Box" on the page.
-|SITE= <scene name='pdbsite=AC1:Iz4+Binding+Site+For+Chain+A'>AC1</scene> and <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=IZ4:N-{(1S)-2-{4-[(5S)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[(4R)-4-(2-PHENYLETHYL)-4,5-DIHYDRO-1H-IMIDAZOL-2-YL]ETHYL}-3-FLUOROBENZENESULFONAMIDE'>IZ4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_2vex|  PDB=2vex  |  SCENE=  }}
-|RELATEDENTRY=[[2f6t|2F6T]], [[2f6f|2F6F]], [[2cnf|2CNF]], [[2cm3|2CM3]], [[2cm2|2CM2]], [[1g1f|1G1F]], [[1q6n|1Q6N]], [[1ptu|1PTU]], [[1c84|1C84]], [[2veu|2VEU]], [[1q1m|1Q1M]], [[1nz7|1NZ7]], [[2azr|2AZR]], [[1c88|1C88]], [[1oet|1OET]], [[1c83|1C83]], [[1sug|1SUG]], [[1onz|1ONZ]], [[1ptv|1PTV]], [[2cnh|2CNH]], [[1xbo|1XBO]], [[1g1g|1G1G]], [[2hnp|2HNP]], [[1t49|1T49]], [[1nwl|1NWL]], [[2f6y|2F6Y]], [[2cne|2CNE]], [[1nl9|1NL9]], [[1c86|1C86]], [[1kav|1KAV]], [[2hnq|2HNQ]], [[1jf7|1JF7]], [[1pxh|1PXH]], [[1q6s|1Q6S]], [[1l8g|1L8G]], [[2cma|2CMA]], [[1q6m|1Q6M]], [[1i57|1I57]], [[1bzj|1BZJ]], [[1wax|1WAX]], [[1ony|1ONY]], [[1g1h|1G1H]], [[2cng|2CNG]], [[1t4j|1T4J]], [[1kak|1KAK]], [[2cni|2CNI]], [[2b07|2B07]], [[2cm8|2CM8]], [[1eeo|1EEO]], [[1ptt|1PTT]], [[1g7g|1G7G]], [[1qxk|1QXK]], [[1ecv|1ECV]], [[1oem|1OEM]], [[2cmb|2CMB]], [[1nwe|1NWE]], [[2fjn|2FJN]], [[1aax|1AAX]], [[2vev|2VEV]], [[2vey|2VEY]], [[2b4s|2B4S]], [[2bgd|2BGD]], [[2cm7|2CM7]], [[1a5y|1A5Y]], [[2cmc|2CMC]], [[1c85|1C85]], [[1lqf|1LQF]], [[1c87|1C87]], [[2f6w|2F6W]], [[1no6|1NO6]], [[1pyn|1PYN]], [[2bge|2BGE]], [[1oes|1OES]], [[1bzc|1BZC]], [[2f6z|2F6Z]], [[2f71|2F71]], [[1q6t|1Q6T]], [[1oeu|1OEU]], [[1g7f|1G7F]], [[1nny|1NNY]], [[1q6j|1Q6J]], [[2f70|2F70]], [[1q6p|1Q6P]], [[2f6v|2F6V]], [[1t48|1T48]], [[2fjm|2FJM]], [[1oeo|1OEO]], [[1pa1|1PA1]], [[1ph0|1PH0]], [[1bzh|1BZH]], [[1gfy|1GFY]], [[1een|1EEN]], [[1pty|1PTY]], [[1oev|1OEV]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vex OCA], [http://www.ebi.ac.uk/pdbsum/2vex PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vex RCSB]</span>
-}}
 '''CRYSTAL STRUCUTRE OF PROTEIN TYROSINE PHOSPHATASE 1B IN COMPLEX WITH AN ISOTHIAZOLIDINONE-CONTAINING INHIBITOR'''
@@ Line 40: / Line 37: @@
 [[Category: Wynn, R.]]
 [[Category: Yue, E W.]]
-[[Category: acetylation]]
+[[Category: Acetylation]]
-[[Category: endoplasmic reticulum]]
+[[Category: Endoplasmic reticulum]]
-[[Category: hydrolase]]
+[[Category: Hydrolase]]
-[[Category: membrane]]
+[[Category: Membrane]]
-[[Category: oxidation]]
+[[Category: Oxidation]]
-[[Category: phosphatase]]
+[[Category: Phosphatase]]
-[[Category: phosphorylation]]
+[[Category: Phosphorylation]]
-[[Category: polymorphism]]
+[[Category: Polymorphism]]
-[[Category: protein phosphatase]]
+[[Category: Protein phosphatase]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:41:48 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:28 2008''