Ectonucleotide pyrophosphatase/phosphodiesterase: Difference between revisions
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<StructureSection load='4gtw' size='400' side='right' caption='Mouse glycosylated Se-Met ENPP1 complex with AMP and Ca+2 (green) and Zn+2 ions (grey) (PDB code [[4gtw]])' scene='77/775922/Cv/1'> | <StructureSection load='4gtw' size='400' side='right' caption='Mouse glycosylated Se-Met ENPP1 complex with AMP and Ca+2 (green) and Zn+2 ions (grey) (PDB code [[4gtw]])' scene='77/775922/Cv/1'> | ||
__TOC__ | |||
== Function == | == Function == | ||
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The active site of ENPP1 contains <scene name='77/775922/Cv/3'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/4'>reaction product AMP</scene><ref>PMID:23027977</ref>. | The active site of ENPP1 contains <scene name='77/775922/Cv/3'>two functionally significant Zn+2 ions</scene> and the <scene name='77/775922/Cv/4'>reaction product AMP</scene><ref>PMID:23027977</ref>. | ||
== 3D Structures of ectonucleotide pyrophosphatase/phosphodiesterase == | |||
[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[4b56]] – mENPP1 – mouse <br /> | **[[4b56]] – mENPP1 – mouse <br /> | ||
**[[2ys0]] – hENPP1 somatomedin domain – human - NMR <br /> | **[[2ys0]] – hENPP1 somatomedin domain – human - NMR <br /> | ||
**[[4gtw]], [[4gtx]], [[4gty]], [[4gtz]] – mENPP1 (mutant) + nucleotide <br /> | **[[4gtw]], [[4gtx]], [[4gty]], [[4gtz]], [[6aek]], [[6ael]] – mENPP1 (mutant) + nucleotide <br /> | ||
*ENPP2 (Autotoxin) | *ENPP2 (Autotoxin) | ||
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**[[6c02]] – hENPP3 + AMPCPP <br /> | **[[6c02]] – hENPP3 + AMPCPP <br /> | ||
**[[6dxo]] - hENPP3 (mutant) + AMPCPP<br /> | **[[6dxo]] - hENPP3 (mutant) + AMPCPP<br /> | ||
**[[6f2t]] – rENPP3 <br /> | **[[6f2t]], [[6g4g]] – rENPP3 <br /> | ||
**[[6f2v]] - rENPP3 + AMP<br /> | **[[6f2v]] - rENPP3 + AMP<br /> | ||
**[[6f2y]] - rENPP3 + Ap4A<br /> | **[[6f2y]] - rENPP3 + Ap4A<br /> | ||