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==Structure of HIV-1 CA G208R== | |||
<StructureSection load='6mqo' size='340' side='right'caption='[[6mqo]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mqo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MQO FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mqo OCA], [http://pdbe.org/6mqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mqo RCSB], [http://www.ebi.ac.uk/pdbsum/6mqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mqo ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The human antiviral protein MxB is a restriction factor that fights HIV infection. Previous experiments have demonstrated that MxB targets the HIV capsid, a protein shell that protects the viral genome. To make the conical-shaped capsid, HIV CA proteins are organized into a lattice composed of hexamer and pentamer building blocks, providing many interfaces for host proteins to recognize. Through extensive biochemical and biophysical studies and molecular dynamics simulations, we show that MxB is targeting the HIV capsid by recognizing the region created at the intersection of three CA hexamers. We are further able to map this interaction to a few CA residues, located in a negatively charged well at the interface between the three CA hexamers. This work provides detailed residue-level mapping of the targeted capsid interface and how MxB interacts. This information could inspire the development of capsid-targeting therapies for HIV. | |||
MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid.,Smaga SS, Xu C, Summers BJ, Digianantonio KM, Perilla JR, Xiong Y Structure. 2019 May 10. pii: S0969-2126(19)30137-6. doi:, 10.1016/j.str.2019.04.015. PMID:31155311<ref>PMID:31155311</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6mqo" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Smaga, S S]] | |||
[[Category: Xiong, Y]] | |||
[[Category: Capsid]] | |||
[[Category: Viral protein]] | |||