Transfer RNA (tRNA): Difference between revisions
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'''Modified nucleotides.''' Most tRNAs contain modified nucleotides[2], which are added post-transcriptionally by specific enzymes. Common modifications include isomerisation of uridines into pseudouridines (Ψ), methylation of either the ribose and/or the base, thiolation, reduction of uridines into dihydrouridines (D). The anticodon loop of the tRNA quite often contains hypermodified bases, the function of which is to stabilize the codon-anticodon interaction within the ribosome. The nature and position of nucleotide modifications is both specific of the organism and the tRNA type. Common modified nucleotides include : | '''Modified nucleotides.''' Most tRNAs contain modified nucleotides[2], which are added post-transcriptionally by specific enzymes. Common modifications include isomerisation of uridines into pseudouridines (Ψ), methylation of either the ribose and/or the base, thiolation, reduction of uridines into dihydrouridines (D). The anticodon loop of the tRNA quite often contains hypermodified bases, the function of which is to stabilize the codon-anticodon interaction within the ribosome. The nature and position of nucleotide modifications is both specific of the organism and the tRNA type. Common modified nucleotides include : | ||
* 5-methyluridine (ribothymidine) at position 54 | * 5-methyluridine (ribothymidine) at position 54 | ||
* pseudouridine at position 55 | * <scene name='43/433638/Pseudouridine/1'>pseudouridine at position 55</scene> | ||
* dihydrouridine(s) in the D-loop | * dihydrouridine(s) in the D-loop | ||
* 7-methylguanosine at position 46 | * 7-methylguanosine at position 46 | ||