Ragulator complex: Difference between revisions

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The '''ragulator complex''' (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it<ref>PMID:29285400</ref>.
The '''ragulator complex''' (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it<ref>PMID:29285400</ref>.
== Function ==
== Disease ==
== Relevance ==
== Structural highlights ==




Revision as of 11:33, 25 October 2018


The ragulator complex (Lamtor) is a pentamer which recruits mTORC1 in the rapamycin (mTOR) signal-transduction pathway and activates it[1].


Human ragulator complex proteins: LAMTOR1 coiled coil domain (grey and cyan) + LAMTOR2 roadblock domain (green and red) + LAMTOR3 roadblock domain (pink and gold) + LAMTOR4 roadblock domain (yellow and wheat) + LAMTOR5 roadblock domain (magenta and blue) PDB code 5y39

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3D structures of ragulator complex3D structures of ragulator complex

Updated on 25-October-2018

6b9x - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + hepatitis B virus interacting protein - human
5y39, 5y3a, 6ehp - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
5x6u - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5
6ehr - hLAMTOR1 + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
5x6v - hLAMTOR1 (mutant) + LAMTOR2 + LAMTOR3 + LAMTOR4 + LAMTOR5 + Ras-related GTP-binding proteins A, C
5vok, 5y38 - hLAMTOR4 + LAMTOR5

ReferencesReferences

  1. ↑ Mu Z, Wang L, Deng W, Wang J, Wu G. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discov. 2017 Dec 26;3:17049. doi: 10.1038/celldisc.2017.49. eCollection, 2017. PMID:29285400 doi:http://dx.doi.org/10.1038/celldisc.2017.49

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Michal Harel, Wayne Decatur
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