5dl1: Difference between revisions

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==ClpP from Staphylococcus aureus in complex with AV145==
==ClpP from Staphylococcus aureus in complex with AV145==
<StructureSection load='5dl1' size='340' side='right' caption='[[5dl1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='5dl1' size='340' side='right'caption='[[5dl1]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dl1]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DL1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dl1]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DL1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5C2:1-(PROPAN-2-YL)-N-{[2-(THIOPHEN-2-YL)-1,3-OXAZOL-4-YL]METHYL}-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE'>5C2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v5e|3v5e]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5C2:1-(PROPAN-2-YL)-N-{[2-(THIOPHEN-2-YL)-1,3-OXAZOL-4-YL]METHYL}-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE'>5C2</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">clpP, SAB0722 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl1 OCA], [https://pdbe.org/5dl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dl1 RCSB], [https://www.ebi.ac.uk/pdbsum/5dl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dl1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_Clp Endopeptidase Clp], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.92 3.4.21.92] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dl1 OCA], [http://pdbe.org/5dl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5dl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dl1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLPP_STAAB CLPP_STAAB]] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.  
[https://www.uniprot.org/uniprot/CLPP_STAA8 CLPP_STAA8] Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Clp Protease|Clp Protease]]
*[[Clp protease 3D structures|Clp protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Endopeptidase Clp]]
[[Category: Large Structures]]
[[Category: Groll, M]]
[[Category: Staphylococcus aureus]]
[[Category: Vielberg, M T]]
[[Category: Groll M]]
[[Category: Allosteric regulation]]
[[Category: Vielberg M-T]]
[[Category: Binding analysis]]
[[Category: Caseinolytic protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

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