2reb: Difference between revisions

Revision as of 16:44, 4 May 2008

THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER

OverviewOverview

The crystal structure of the recA protein from Escherichia coli at 2.3-A resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the N and C termini protrude from the protein and respectively stabilize a 6(1) helical polymer of protein subunits and interpolymer bundles. This polymer structure closely resembles that of recA/DNA filaments determined by electron microscopy. Mutations in recA protein that enhance coprotease, DNA-binding and/or strand-exchange activity can be explained if the interpolymer interactions in the crystal reflect a regulatory mechanism in vivo.

About this StructureAbout this Structure

2REB is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

ReferenceReference

The structure of the E. coli recA protein monomer and polymer., Story RM, Weber IT, Steitz TA, Nature. 1992 Jan 23;355(6358):318-25. PMID:1731246 Page seeded by OCA on Sun May 4 16:44:16 2008

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OCA

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 [[Image:2reb.gif|left|200px]]
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 '''THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER'''
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 [[Category: Steitz, T A.]]
 [[Category: Story, R M.]]
-[[Category: homologous recombination]]
+[[Category: Homologous recombination]]
-[[Category: self-cleavage stimulation]]
+[[Category: Self-cleavage stimulation]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:44:16 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:59:28 2008''