PTEN function: Difference between revisions
m Initial view was of Streptavidin |
Michal Harel (talk | contribs) No edit summary |
||
| Line 5: | Line 5: | ||
<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='78/786030/Pten_molecule/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='78/786030/Pten_molecule/1'> | ||
== Function == | == Function == | ||
PTEN is a dual phosphatase and tumor suppressor protein that interacts with LKB-1. It is composed of a C-terminal and N-Terminal. The C-Terminal is a C2 Domain, this targets proteins to cell membranes. The N-terminal is a Phosphatase Domain, it’s job is to remove phosphate groups from a | PTEN is a dual phosphatase and tumor suppressor protein that interacts with LKB-1. It is composed of a C-terminal and N-Terminal. The C-Terminal is a C2 Domain, this targets proteins to cell membranes. The N-terminal is a Phosphatase Domain, it’s job is to remove phosphate groups from a phosphorylated amino acid. | ||
== Disease == | == Disease == | ||
The protein is located on the 10th chromosome 10q23.31 in humans. PTEN works with tumor suppressing for cancers, such as breast and prostate cancer. It also works to remove phosphate groups from specific amino acids, such as dephosphorylating tyrosine, serine, and threonine phosphorylated peptides. | The protein is located on the 10th chromosome 10q23.31 in humans. PTEN works with tumor suppressing for cancers, such as breast and prostate cancer. It also works to remove phosphate groups from specific amino acids, such as dephosphorylating tyrosine, serine, and threonine phosphorylated peptides. | ||