Signal recognition particle receptor

Signal recognition particle receptor (SRPR) is associated with the endoplasmic reticulum. SRPR is a receptor for the signal recognition particle (SRP). SRPR is a heterodimer with α and β subunits which contain a GTP-binding domain. SRPR α subunit binds to SRP54 subunit of SRP complex. SRPR β subunit is a transmembrane GTPase. The bacterial SRPR is called FtsY. . Water molecules shown as red spheres. .

spinqualitylabelsall models Human SRPR α (magenta) and β subunit (deepskyblue) complex with GTP and Mg+2 (green) ion 2fh5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of signal recognition particle receptor3D structures of signal recognition particle receptor

Updated on 20-September-2018

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• Signal recognition particle receptor
  • 1nrj – ySRPR α+β subunits + GTP – yeast
    
  • 2fh5 - hSRPR α+β subunits + GTP – human
    
  • 5l3q - hSRPR α subunit + SRP54 + AMP + GNP
    
  • 2ged - ySRPR β subunit (mutant)
    
  • 2go5 - hSRPR α subunit + mSRPR β subunit + ribosomal proteins L23, L31, L35 + dSRP19 + dSRP54 + RNA - EM
    
  • 3dm9, 3dmd, 3e70 – SRPR + GDP – Pyrococcus furiosus
• Signal recognition particle receptor FtsY
  • 1zu5, 1zu4 – SRPR FtsY NG domain – Mycoplasma mycoides
    
  • 1vma – SRPR FtsY – Thermotoga maritima
    
  • 6cy – EaSRPR FtsY – Elizabethkingia anopheles
    
  • 6cy5 – EaSRPR FtsY NG domain + GDP
    
  • 2q9a – TaSRPR FtsY – Thermus aquaticus
    
  • 2q9c, 2q9b – TaSRPR FtsY NG domain + GMPPNP
    
  • 2yhs, 2qy9, 1fts, 6cqp – EcSRPR FtsY NG domain – Escherichia coli
    
  • 6fqd – EcSRPR FtsY NG domain + GDP
    
  • 6c58, 6cvd, 6dlx – EcSRPR FtsY NG domain + antibiotic
    
  • 2iyl – EcSRPR FtsY residues 20-303 + GDP
    
  • 2xxa - EcSRPR FtsY NG domain + signal recognition particle protein residues 1-433 (mutant) + 4.5SRNA
    
  • 3zn8 - EcSRPR FtsY NG domain + signal recognition particle protein 54 NG domain + 4.5SRNA + dipeptidyl aminopeptidase B
    
  • 2j7p, 1rj9, 1okk – TaSRPR FtsY NG domain + signal recognition particle protein – Thermus aquaticus
    
  • 2cnw – TaSRPR FtsY NG domain + signal recognition particle protein + GDP
    
  • 4c7o – EcFtsY + EcSRP + SRP RNA
    
  • 2xkv – EcFtsY + EcSRP NG+M domains + 4.5S RNA
    
  • 5aka, 5gad, 5nco, 5gaf, 5gag, 5gah – EcFtsY in ribosome - Cryo EM
    
  • 3jaj, 3jan – FtsY in ribosome - rabbit - Cryo EM
    
  • 5l3r – SRPR FtsY + SRP54 - Arabidopsis thaliana
    
  • 5l3w – SRPR FtsY NG domain - Sulfolobus acidocaldarius
    
  • 5l3s – SRPR FtsY + SRP54 + GNP - Sulfolobus solfataricus