6me5: Difference between revisions
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==XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine== | |||
<StructureSection load='6me5' size='340' side='right'caption='[[6me5]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6me5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ME5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ME5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AWY:~{N}-[2-(7-methoxynaphthalen-1-yl)ethyl]ethanamide'>AWY</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr> | |||
[[Category: | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6me5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6me5 OCA], [http://pdbe.org/6me5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6me5 RCSB], [http://www.ebi.ac.uk/pdbsum/6me5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6me5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/MTR1A_HUMAN MTR1A_HUMAN]] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Batyuk, A]] | |||
[[Category: Brehm, W]] | |||
[[Category: Cherezov, V]] | |||
[[Category: Gati, C]] | |||
[[Category: Grandner, J M]] | |||
[[Category: Grant, T D]] | |||
[[Category: Han, G W]] | |||
[[Category: Ishchenko, A]] | |||
[[Category: Johansson, L C]] | |||
[[Category: Katritch, V]] | |||
[[Category: Liu, W]] | |||
[[Category: Madsen, C]] | |||
[[Category: McCorvy, J D]] | |||
[[Category: Michaelian, N]] | |||
[[Category: Olsen, R H.J]] | |||
[[Category: Patel, N]] | |||
[[Category: Roth, B L]] | |||
[[Category: Stauch, B]] | |||
[[Category: Tribo, A R]] | |||
[[Category: Weierstall, U]] | |||
[[Category: White, T A]] | |||
[[Category: Zhu, L]] | |||
[[Category: Agomelatine]] | |||
[[Category: Circadian rhythm]] | |||
[[Category: Gpcr]] | |||
[[Category: Jetlag]] | |||
[[Category: Lcp]] | |||
[[Category: Membrane protein]] | |||
[[Category: Pg]] | |||
[[Category: Xfel]] | |||
Revision as of 09:57, 24 April 2019
XFEL crystal structure of human melatonin receptor MT1 in complex with agomelatineXFEL crystal structure of human melatonin receptor MT1 in complex with agomelatine
Structural highlights
Function[MTR1A_HUMAN] High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
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