6hl0: Difference between revisions

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-'''Unreleased structure'''
-The entry 6hl0 is ON HOLD  until Paper Publication
+==Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide==
+<StructureSection load='6hl0' size='340' side='right'caption='[[6hl0]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
-Authors: Kudlinzki, D., Merk, D., Linhard, V.L., Saxena, K., Schubert-Zsilavecz, M., Schwalbe, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6hl0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HL0 FirstGlance]. <br>
-Description: Crystal Structure of Farnesoid X receptor (FXR) with bound NCoA-2 peptide
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hl0 OCA], [http://pdbe.org/6hl0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hl0 RCSB], [http://www.ebi.ac.uk/pdbsum/6hl0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hl0 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Linhard, V.L]]
+== Function ==
+[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Kudlinzki, D]]
+[[Category: Linhard, V L]]
+[[Category: Merk, D]]
 [[Category: Saxena, K]]
 [[Category: Schubert-Zsilavecz, M]]
-[[Category: Merk, D]]
 [[Category: Schwalbe, H]]
+[[Category: Activator]]
+[[Category: Complex]]
+[[Category: Dna-binding]]
+[[Category: Nuclear protein]]
+[[Category: Receptor]]
+[[Category: Repressor]]