Ryanodine receptor: Difference between revisions
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== Disease == | == Disease == | ||
Mutations in RyR are associated with skeletal muscle disorders and triggered cardiac arrhythmia<ref>PMID:23459219</ref><ref>PMID:10790202</ref>. The N-terminal of RYR was found to be the disease hot spot of the molecule<ref>PMID:21048710</ref>. | Mutations in RyR are associated with skeletal muscle disorders and triggered cardiac arrhythmia<ref>PMID:23459219</ref><ref>PMID:10790202</ref>. The N-terminal of RYR was found to be the disease hot spot of the molecule<ref>PMID:21048710</ref>. | ||
== 3D Structures of ryanodine receptor == | |||
[[Ryanodine receptor 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[2xoa]] – rRyR1 N terminal residues 1-559<br /> | **[[2xoa]] – rRyR1 N terminal residues 1-559<br /> | ||
**[[4i0y]], [[4i1e]], [[4i2s]], [[4i37]], [[4i3n]], [[4i6i]], [[4i8m]] – rRyR1 N terminal residues 1-559 (mutant)<br /> | **[[4i0y]], [[4i1e]], [[4i2s]], [[4i37]], [[4i3n]], [[4i6i]], [[4i8m]] – rRyR1 N terminal residues 1-559 (mutant)<br /> | ||
**[[4i7i]] – rRyR1 N terminal residues 1-536 (mutant)<br /> | |||
**[[4i96]] – rRyR1 N terminal residues 217-536 <br /> | **[[4i96]] – rRyR1 N terminal residues 217-536 <br /> | ||
**[[5c33]] – rRyR1 SPRY1 domain residues 650-844 <br /> | **[[5c33]] – rRyR1 SPRY1 domain residues 650-844 <br /> | ||
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**[[6foo]] – rRyR1 + ATP – Cryo EM <br /> | **[[6foo]] – rRyR1 + ATP – Cryo EM <br /> | ||
**[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br /> | **[[3j8h]] – rRyR1 + FKBP12 – Cryo EM <br /> | ||
**[[5y9v]] – | **[[5y9v]] – dmRyR1 N terminal - diamondback moth <br /> | ||
**[[6j6o]], [[6j6p]] – dmRyR1 phosphorylation domain residues 2836-3050 (mutant) <br /> | |||
*Ryanodine receptor 2 (Cardiac Ca+2 release channel); domains - N terminal 1-547; SPRY2 1080-1253; phosphorylation 2699-2904 | *Ryanodine receptor 2 (Cardiac Ca+2 release channel); domains - N terminal 1-547; SPRY2 1080-1253; phosphorylation 2699-2904 | ||